Student Results

Patents

• Rotating device and method for continuous fabrication of long biological tubes. - Gina Scott (Class of 2015), World Intellectual Property Organization, 26 May 2017

• Instruments and methods for loading cells into implantable devices. - Leah (Dixon) Elliot (Class of 2014), World Intellectual Property Organization, 26 May 2016

Publications

• A FZD7 - specific antibody - drug conjugate induces ovarian tumor regression in preclinical models. - Alessandra Rodriguez y Baena (Class of 2018, 6th Author). Molecular Cancer Therapeutics, 19 Oct. 2021.

• Endothelialized Silicone Aneurysm Models for In Vitro Evaluation of Flow Diverters. - Gabriella Graham (Class of 2020, 3rd Author). Journal of Neurointerventional Surgery, Aug 2021. 

• Mechanistic and therapeutic distinctions between cardio-derived cell and mesenchymal stem cell extracellular vesicle non-coding RNA. - Sasha Smolgovsky (Class of 2018, 2nd Author), Tanner Quon (Class of 2018, 7th Author), and Lauren Kelly (Class of 2017, 4th Author). Scientific Reports, Apr 2020. 
• Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation. - Alison Chambon (Class of 2018, 4th author), Kristina Bishard (Class of 2017, 5th author), Nature Materials, Nov 2020
• Brain cell type-specific enhancer-promoter interactome maps and disease - risk association. - Zahara Keulen (Class of 2019, 11th author), Science, Nov 2019
• Determination of Immune Cell Identity and Purity Using Epigenetic-Based Quantitative PCR. -  Stephanie Switalski (Class of 2019, 4th author), Mark Landon (Class of 2019, 5th author), J Vis Exp, Feb 2020
• The evolution of stem cells, disease modeling, and drug discovery for neurological disorders. - Ryan O'Donnell (Class of 2017, 3rd author), Stem Cells Dev, Feb 2020
• Autologus and Heterologous Cell Therapy for Hemophilia B toward Functional Restoration of Factor IX. - Derek Wampler (Class of 2017, 6th author), Cell Reports, Volume 23, Number 5, March 2018 

• Autologous adipose-derived regenerative cell therapy modulates development of hypertrophic scarring in a red Duroc porcine model. - Diana Zafra (Class of 2016, 2nd author), Stem Cell Research & Therapy, Volume 8, Number 1, November 2017

• Different requirements of functional telomeres in neural stem cells and terminally differentiated neurons. - Charles Clapp (Class of 2013, 4^th author), Genes & Development, Volume 31, Number 7, April 2017

• Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss. - Robert Chacon (Class of 2013, 3^rd author), Justin Blonigan (Class of 2015, 4^th author), Victor Garcia (Class of 2014, 5^th author), Patrick Paine (Class of 2016, 8^th author), Nature Communications, Volume 8, June 2017

• Development of a combined radiation and full thickness burn injury minipig model to study the effects of uncultured adipose-derived regenerative cell therapy in wound healing – Diana Zafra (Class of 2016, 5th author), International Journal of Radiation Biology, Volume 93, Number 3, March 2017

• An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy. - Robert Chacon (Class of 2013, 6th author), Michael Gibbons (Class of 2013, 7th author), and Victor Garcia (Class of 2014, 8th author), Nature Biotechnology, Volume 34, Issue 7, pp. 752-759, July 2016

• In vivo imaging of dendritic pruning in dentate granule cells. - Cooper Bloyd (Class of 2015, 2nd author), Nature Neuroscience, Volume 19, Issue 6, pp. 788-791, June 2016

• Tracking of Normal and Malignant Progenitor Cell Cycle Transit in a Defined Niche. - Gennarina Riso (Class of 2014, 5th author), Scientific Reports, Volume 6, p. 23,885, April 2016

• Treatment of Inherited Eye Defects by Systemic Hematopoietic Stem Cell Transplantation - Sarah Ur (Class of 2013, 3rd author), Invest Ophthalmol Vis Sci, Volume 56, Issue 12, pp. 7214-7123, November 2015

• Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells - Josh Cutts (Class of 2014, 3rd author), eLife, Volume 4, pii e08413, November 2015

• Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs - Greg Parker (Class of 2014, 3rd author), Ben Lewis (Class of 2015, 5th author), and Carl Dargitz (Class of 2013, 7th author), Cell Reports, Volume 12, Issue 9, pp. 1385-1390, September 2015

• Adipose-Derived Regenerative Cell Therapy for Burn Wound Healing: A Comparison of Two Delivery Methods - Stephan Teodosescu (Class of 2015, 3rd author), Advances in Wound Care, Volume 00, Number 00, September 2015

• A chemically defined substrate for the expansion and neuronal differentiation of human pluripotent stem cell-derived neural progenitor cells - Josh Cutts (Class of 2014, 2nd author), Volume 5, Issue 1, pp. 75-87, July 2015

• Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells - Carl Dargitz (Class of 2013, 2nd author), PNAS, Volume 111, Issue 17, April 2015

• Lymphoid Regeneration from Gene-Corrected SCID-X1 Subject-Derived iPSCs - Blake Gilmore (Class of 2013, 6th author), Leif Anderson (Class of 2012, 9th author), and Andrew Bornzin (Class of 2012, 10th author), Cell Stem Cell, Volume 16, Issue 4, pp. 367–372, April 2015

  • Video Link Here - Immune system-in-a-dish offers hope for "bubble boy" disease

• Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates - Tommy Harper (Class of 2011, 5th author) and Jeff Palmer (Class of 2013, 8th author), Cell Stem Cell, Volume 16, Issue 4, pp. 386-399, February 2015

• Lysosomal cross-correction by hematopoietic stem cell-derived macrophages via tunneling nanotubes - Sarah Ur (Class of 2013, 7th author), Stem Cells, Volume 33, Issue 1, pp. 301-309, January 2015

• Endogenous WNT signaling regulates hPSC-derived neural progenitor cell heterogeneity and specifies their regional identity - Josh Cutts (Class of 2014, 2nd author), Stem Cell Reports, Volume 3, Issue 6, pp. 1015-28, December 2014

• A Rare Human Syndrome Provides Genetic Evidence that WNT Signaling Is Required for Reprogramming of Fibroblasts to Induced Pluripotent Stem Cells - Ellen Mintz (Class of 2014, 3rd author), Cell Reports, Volume 9, Issue 5, pp. 1770-1780, December 2014

• Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells - Anna McCann (Class of 2011, 5th author), Nature Communications, Volume 5, Article 4430, July 2014

• rAAV9 combined with renal vein injection is optimal for kidney-targeted gene delivery: conclusion of a comparative study - Sarah Ur (Class of 2013, 2nd author), Gene Ther, volume 21, Issue 6, pp. 616-628, May 2014

• Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape - Kaitlyn Kirk (Class of 2011, 1st author), Stem Cell Research, Volume 12, Issue 3, May 2014

• Wnt3a reestablishes osteogenic capacity to bone grafts from aged animals - Whitney Cole (Class of 2012, 9th author), JBJS, Volume 95, Issue 14, pp. 1278-1288, July 2013

• ADAR 1 Promotes Malignant Progenitor Reprogramming In Chronic Myeloid Leukemia - Jane Isquith (Class of 2013, 6th author), PNAS, Volume 110, Issue 3, pp. 1041-1046, January 2013

• Myotonia congenita with strabismus in a large family with a mutation in the SCN4A gene - Kyle Schaf (Class of 2012, 8th author), Eye (Lond), Volume 26, Issue 8, pp. 1039-1043, June 2012